![]() In particular, OCT imaging has been important in decisions regarding treatment with intravitreal anti-angiogenic agents. 1 In clinical practice, the decision to recommend treatment for exudative AMD is dependent on the ability of the clinician to detect and characterize the presence of intraretinal and/or subretinal fluid (SRF) indicative of exudative activity. Optical coherence tomography (OCT) evaluation of macular structure has a central function in the clinical diagnosis and management of patients with age-related macular degeneration (AMD). ![]() Clinical trials using OCT-based clinical evaluations of exudative AMD may need to account for these inter-system differences in planning and analysis. Spectral-domain OCT systems may be able to generate more consensus in clinical interpretation and, in particular cases, detect disease activity not detected by time-domain systems. The choice of time-domain (Stratus) vsspectra-domain (Cirrus) OCT systems has a measurable impact on clinical decision making in exudative AMD. A pair-wise comparison of Cirrus OCT with Stratus OCT systems revealed that Cirrus-based gradings more frequently reported the presence of SRF and IRF and detected overall neovascular activity at a higher rate ( P<0.05) compared with Stratus-based gradings. ResultsĬirrus OCT generated a higher degree of inter-grader consensus than Stratus OCT with higher intraclass correlation coefficients for all parameters analysed. The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analysed. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). ![]() Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus OCT system and the spectral-domain Cirrus OCT system at the same visit. To determine whether optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD).
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